Prothiaden (Prothiaden)

Prothiaden product description

Prothiaden is a tricyclic antidepressant. It has an antidepressant and anxiolytic effect, which develops on the 3-5th day after one started taking the drug. It also has cholinolytic activity. Indications for use:

Depression (especially with anxiety, agitation and sleep disorders, including in childhood, endogenous, involutional, reactive, neurotic, drug-induced, with organic brain lesions, alcohol withdrawal), schizophrenic psychoses, mixed emotional disorders, behavioral and attention disorders, enuresis (except for patients with bladder hypotonia), incontinence, bulimia nervosa, chronic pain syndrome (chronic pain in cancer patients, migraine, preparation for surgery of patients with elevated the level of anxiety, psychogenic impotence.

The mechanism of antidepressant action is associated with an increase in the concentration of noradrenaline in synapses and/or serotonin in the central nervous system (a decrease in their reverse absorption). Accumulation of these neurotransmitters occurs as a result of inhibition of their inverse capture by the membranes of presynaptic neurons. With prolonged use, the medicine reduces the functional activity of beta-adrenergic and serotonin receptors in the brain, normalizes adrenergic and serotonergic transmission, restores the balance of these systems, disturbed in depressive states. With anxiety-depressive states reduces anxiety, agitation, and depressive manifestations.

Prothiaden safety information

The initial dose is 25-50 mg/day, most of the dose is given before bedtime. The maximum dose is 450 mg (for inpatients). With psychogenic impotence, 25 mg is prescribed at night. The minimum duration of treatment is 3 months. The maximum daily dose for children is 100 mg. The course of treatment with Protiaden starts from 3 months. It is necessary for the dosage to be prescribed by the attending physician, who has information on the patient's general health condition and clearly knows his diagnosis.

Prothiaden is incompatible with MAO inhibitors, phenytoin, adrenoblockers, phenothiazines, benzodiazepines, sympathomimetics, thyroid hormone drugs.

The drug is cautiously prescribed for patients with epilepsy. The drug therapy can be started not earlier than two weeks after stopping the intake of MAO inhibitors. Among the contraindications for taking medication are the following: closed-angle glaucoma, prostate adenoma, obstructive conditions of the digestive system, atony of the bladder, the first trimester of pregnancy.

Prothiaden side effects

Side effects of dozulepin are less common and weaker than in other antidepressants. Among them, there are cases of allergic reactions to the components of the drug, delayed urination, disruption of accommodation, constipation, tachycardia, hypotension, dry mouth, fatigue, drowsiness, dizziness. With prolonged admission, estrogen-like effects are possible. The drug is not used simultaneously with MAO inhibitors, phenytoin, adrenoblockers, phenothiazines, benzodiazepines, sympathomimetics, thyroid hormone preparations. The drug has a thymoleptic and anxiolytic effect.